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Systematic Reviews

Systematic Reviews & Meta-analysis

OXON performs systematic reviews and meta-analyses to inform healthcare decisions and policies

Advances in methodology and creation of standards have improved the reliability and consistency of these syntheses of research findings.



Systematic reviews aim to identify, evaluate, and summarize the findings of all relevant individual studies over a health-related issue, thereby making the available evidence more accessible to decision makers.

OXON conducts systematic reviews of epidemiological, registry, safety, PRO, health economic and trial data. Often we proceed to synthesise these data using meta-analysis. However, a qualitative systematic review is conducted where meta-analysis is not possible or appropriate.

We use the standardised methodology of Cochrane for trial evidence and diverse alternative methodologies for non-experimental evidence.

Cochrane Database of Systematic Reviews


Systematic reviews sometimes use statistical techniques (meta-analysis) to combine results of eligible studies. 

A systematic review is a quantitative, formal, epidemiological study design used to systematically assess previous research studies to derive conclusions about that body of research.  Outcomes may include a more precise estimate of the effect of treatment or risk factor for disease, or other outcomes, than any individual study.

OXON conducts systematic reviews and meta-analysis of epidemiological, registry, safety, PRO, health economic and trial data to support:

• Prevalence estimates for orphan drug applications
• Submission of drugs during the integrated safety summary in the Common Technical Document (CTD)
• Disease models
• Evidence-based decision-making
• Combination of data from different patient registries
• Direct and indirect meta-analyses to support cost-effectiveness models
• Aggregated and individual-person data meta-analysis.

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