Systematic Reviews & Meta-analysis
OXON performs systematic reviews and meta-analyses to inform healthcare decisions and policies
Advances in methodology and creation of standards have improved the reliability and consistency of these syntheses of research findings.
OXON conducts systematic reviews of epidemiological, registry, safety, PRO, health economic and trial data. Often we proceed to synthesise these data using meta-analysis. However, a qualitative systematic review is conducted where meta-analysis is not possible or appropriate.
We use the standardised methodology of Cochrane for trial evidence and diverse alternative methodologies for non-experimental evidence.
Cochrane Database of Systematic Reviews
OXON conducts systematic reviews and meta-analysis of epidemiological, registry, safety, PRO, health economic and trial data to support:
• Prevalence estimates for orphan drug applications
• Submission of drugs during the integrated safety summary in the Common Technical Document (CTD)
• Disease models
• Evidence-based decision-making
• Combination of data from different patient registries
• Direct and indirect meta-analyses to support cost-effectiveness models
• Aggregated and individual-person data meta-analysis.