FREE LIVE DEBATE “When can RWE be relied on to complement or replace evidence from RCTs to guide clinical decisions?”
By leading Professors from Harvard, Oxford, London
DATE: October 5, 2023, at 5pm CEST | 4pm UK time | 11am EST.
OXON Epidemiology bring together for this live debate two leading proponents who believe that observational studies can provide evidence on effectiveness and safety that is sufficiently reliable to guide clinical decisions and two leading critics of this approach.
This debate is timely as Real World Evidence (RWE) is being used increasingly to assess the effectiveness and safety of medications and devices. The results from comparisons of RWE and RCTs for the effectiveness of drugs is being taken up by US and European regulators and reimbursement agencies.
OXON Epidemiology will host this FREE LIVE ONLINE DEBATE on Thursday, 5 October 2023.
During this 90-minute event there will be a highly informative and lively debate with two leading proponents who believe that observational studies can provide evidence on effectiveness and safety that is sufficiently reliable to guide clinical decisions and two critics of this approach. There will then be discussion among the speakers and questions from the virtual audience.
The debate will focus on the following areas:
- When observational studies may be helpful
- When randomized trials are necessary
- When observational studies and randomized trials can complement each otherEVENT, Event
- How randomized trials can be made more relevant to real world clinical practice.
-INTRODUCTION BY MODERATOR
- Nawab Qizilbash, Senior Clinical Epidemiologist, OXON Epidemiology
Honorary Associate Professor, London School of Hygiene and Tropical Medicine and former Honorary Consultant Physician, Oxford.
-15-MINUTE SPEAKERS PRESENTATIONS
- Miguel Hernan, Professor of Epidemiology and Biostatistics, Harvard
A leading epidemiologist whose CAUSALab group has developed causal inference methods and published multiple comparisons of RWD and randomized trials.
- Martin Landray, Professor of Medicine and Epidemiology, Oxford
A leading trialist and epidemiologist whose general position on this topic is captured by his NEJM sounding board article (2020): ´ The Magic of Randomization versus the Myth of Real-World Evidence´.
- Sebastian Schneeweiss, Professor of Medicine and Epidemiology, Harvard Medical School
A leading epidemiologist whose group, with the participation of FDA scientists, attempted to emulate 30 completed trials and predict the outcome of 7 ongoing trials using real-world data at scale, applying a prespecified approach.
- Stuart Pocock, Professor of Medical Statistics, London School of Hygiene and Tropical Medicine
A leading trialist whose general position on this topic is captured by his NEJM editorial (2000) ‘Randomized Trials or Observational Tribulations?’
None of the speakers have a relationship with OXON, except Stuart Pocock. All speakers volunteer their time for this event as a service to health researchers and regulators.
-DISCUSSION BETWEEN THE SPEAKERS: 20 MINUTES
-Q & A FROM AUDIENCE TO SPEAKERS: 10 MINUTES
Don’t miss the opportunity to ask questions and share thoughts with these academic leaders for what promises to be a lively and informative debate, and click below to register for the event.